New PDF release: Adenosine and Adenine Nucleotides: From Molecular Biology to

By Marlene A. Jacobson (auth.), Luiz Belardinelli, Amir Pelleg (eds.)

This e-book incorporates a choice of lectures given in the course of the fifth overseas Symposium on Adenosine and Adenine Nucleotides, lately held in Philadelphia, Pennsylvania.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology covers quite a lot of matters from molecular and mobile biology to scientific functions. a very good emphasis has been put on innovative details derived from reports utilizing molecular and mobile biology ideas utilized to the sector of adenosine and adenine nucleotide learn. The ebook additionally contains info on in all probability promising advancements within the healing functions of adenosine similar medications and ATP. The culture of previous conferences can be maintained through together with within the software displays of recent study within the parts of purine metabolism and body structure, and pharmacology of adenosine and adenine nucleotides.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology is a superb, updated reference ebook for easy and medical scientists within the box of adenosine and adenine nucleotides.

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Extra resources for Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

Example text

In the three studied species, a differential compartmentalization of A2a receptor expression in striosomes or matrix could not be detected during adulthood {3-5,14,15}. However, during brain development the striosomes were transiently enriched in A2a receptors {15, 16}, and this corresponds at the cellular level to a 24 I. MOLECULAR AND CELLULAR BIOLOGY OF ADENOSINE AND ATP A 9 ". - 2 ,6 7 .. --------A 2r , higher density of labeled neurons in the patch areas together with a higher level of expression per labeled patch neuron as compared with the matrix neurons.

Mahan LC, McVittie LD, Smyk-Randall EM, Nakata H, Monsma F] ]r, Gerfen CR, Sibley DR (1991) Cloning and expression of an Al adenosine receptor from rat brain. Mol Pharmacol 40: 1-7 . Fink ]S, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM (1992) Molecular cloning of the rat A2 adenosine receptor: Selective co-expression with D2 dopamine receptors in rat striatum. Mol Brain Res 14:186-195. Schiffmann SN, Vanderhaeghen J] (1992) Ontogeny of gene expression of adenosine A2 receptor in the striatum: Early localization in the patch compartment.

The subsequent cloning of the A3 receptor from sheep {25} and human {26J brain showed that in these species this receptor was sensitive to acidic xanthines. Given these discrepancies in xanthine sensitivity and the approximate 75 % sequence homology between the human and rat A3 receptors, it is conceivable that the observed species differences in pharmacology could be considered a reflection of distinct receptor subtypes. An important point in regard to receptor structure as determined by cloning and expression, and function, as determined initially by pharmacologic profile, is whether sequence homology, or lack thereof, can be used to determine probable function.

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