New PDF release: Advances in Chromatographic Techniques for Therapeutic Drug

By Amitava Dasgupta

For medications with a slender healing index, healing drug tracking tools are crucial for sufferer administration. even if immunoassays are commercially to be had for plenty of medicinal drugs and such a lot laboratories use those assays for regimen healing tracking, they've got many boundaries which prevent their efficacy. supplying sensible instructions for enforcing hottest gasoline and liquid chromatographic tools, Advances in Chromatographic ideas for healing Drug tracking is a accomplished reference describing the speculation and alertness of healing drug tracking in medical laboratories. Edited via a special authority within the box and containing contributions from quite a few specialists, the e-book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, matters on the topic of ache administration and natural supplementations, and healing drug tracking for quite a number medicinal drugs, together with: Anticonvulsants Digitalis Cardioactive medicinal drugs Antidepressants Immunosuppressants Anti-cancer medicinal drugs Vancomycin and aminoglycosides Antibiotics Antiretroviral medications Nonnarcotic analgesics anti inflammatory medicinal drugs ? Examing older and more moderen medicines, the publication includes specific discussions at the motive for healing drug tracking of every type of gear, in addition to their uncomplicated pharmacology and toxicology. an intensive record of references is equipped on the finish of every bankruptcy in order that these drawn to imposing a brand new drug assay can locate the main acceptable technique for the meant drug.

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Extra info for Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

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This drug does not undergo any significant intestinal or hepatic metabolism. Recent developments indicate that the family of drug uptake transporters known as organic anion transporting polypepetides (OATPs) plays an important role in disposition of certain drugs. In the small intestine OATPs facilitate absorption of certain medications and inhibition of this transport system may cause reduced bioavailability. Grapefruit juice (300 or 1200 ml) produced lower mean maximum plasma concentration and AUC of fexofenadine compared to when the drug was taken with the same volume of water.

Hypothyroidism is common in pregnancy and therapeutic drug monitoring of antithyroid drugs is important. Consistently lower serum concentrations of propylthiouracil were observed in pregnant women compared to nonpregnant women [66]. In general dosage adjustments are required for anticonvulsants, lithium, digoxin, certain beta blockers, ampicillin, cefuroxime and certain antidepressants in pregnant women. In addition, certain drugs such as tetracycline, antithyroid medications, coumarin anticoagulants, aspirin, indomethacin, opioids, barbiturates, and phenothiazine may have unwanted effects in the fetus despite careful adjustment of maternal dosage [67,68].

However, immunoassays are not commercially available for all drugs currently monitored in clinical practice and various sophisticated techniques such as HPLC combined with tandem mass spectrometry or GC combined with mass spectrometry are used for determination of concentrations of these drugs in biological matrix. There are also many limitations of immunoassays but the major limitations of immunoassays are interferences from drug metabolites, other drugs with similar structures, herbal supplements as well as various endogenous factors.

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