New PDF release: An Evolutionary Perspective - Guidebook

By Barbara J. King

Direction Guidebook for organic Anthropology: An Evolutionary standpoint. Like New situation! get monetary savings by means of ordering the consultant e-book with out the DVD!!!

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In the three studied species, a differential compartmentalization of A2a receptor expression in striosomes or matrix could not be detected during adulthood {3-5,14,15}. However, during brain development the striosomes were transiently enriched in A2a receptors {15, 16}, and this corresponds at the cellular level to a 24 I. MOLECULAR AND CELLULAR BIOLOGY OF ADENOSINE AND ATP A 9 ". - 2 ,6 7 .. --------A 2r , higher density of labeled neurons in the patch areas together with a higher level of expression per labeled patch neuron as compared with the matrix neurons.

Mahan LC, McVittie LD, Smyk-Randall EM, Nakata H, Monsma F] ]r, Gerfen CR, Sibley DR (1991) Cloning and expression of an Al adenosine receptor from rat brain. Mol Pharmacol 40: 1-7 . Fink ]S, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM (1992) Molecular cloning of the rat A2 adenosine receptor: Selective co-expression with D2 dopamine receptors in rat striatum. Mol Brain Res 14:186-195. Schiffmann SN, Vanderhaeghen J] (1992) Ontogeny of gene expression of adenosine A2 receptor in the striatum: Early localization in the patch compartment.

The subsequent cloning of the A3 receptor from sheep {25} and human {26J brain showed that in these species this receptor was sensitive to acidic xanthines. Given these discrepancies in xanthine sensitivity and the approximate 75 % sequence homology between the human and rat A3 receptors, it is conceivable that the observed species differences in pharmacology could be considered a reflection of distinct receptor subtypes. An important point in regard to receptor structure as determined by cloning and expression, and function, as determined initially by pharmacologic profile, is whether sequence homology, or lack thereof, can be used to determine probable function.

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