By Kiyohiko Sugano
A accomplished creation to utilizing modeling and simulation courses in drug discovery and development
Biopharmaceutical modeling has develop into vital to the layout and improvement of latest medications. Influencing key features of the advance strategy, together with drug substance layout, formula layout, and toxicological publicity evaluation, biopharmaceutical modeling is now obvious because the linchpin to a drug's destiny good fortune. And whereas there are many commercially to be had software program courses for drug modeling, there has no longer been a unmarried source guiding pharmaceutical execs to the particular instruments and practices had to layout and attempt secure drugs.
A consultant to the fundamentals of modeling and simulation courses, Biopharmaceutics Modeling and Simulations deals pharmaceutical scientists the keys to knowing how they paintings and are utilized in growing medicines with wanted medicinal houses. starting with a spotlight at the oral absorption of gear, the booklet discusses:
- The critical dogma of oral drug absorption (the interaction of dissolution, solubility, and permeability of a drug), which kinds the foundation of the biopharmaceutical class approach (BCS)
- The inspiration of drug concentration
- How to simulate key drug absorption processes
- The physiological and drug estate facts used for biopharmaceutical modeling
- Reliable practices for reporting results
With over two hundred figures and illustrations and a peerless exam of the entire key points of drug research?including working and studying versions, validation, and compound and formula selection?this reference seamlessly brings jointly the confirmed functional techniques necessary to constructing the secure and potent drugs of tomorrow.
Chapter 1 advent (pages 1–9):
Chapter 2 Theoretical Framework I: Solubility (pages 10–32):
Chapter three Theoretical Framework II: Dissolution (pages 33–63):
Chapter four Theoretical Framework III: organic Membrane Permeation (pages 64–121):
Chapter five Theoretical Framework IV: Gastrointestinal Transit types and Integration (pages 122–159):
Chapter 6 body structure of Gastrointestinal Tract and different management websites in people and Animals (pages 160–205):
Chapter 7 Drug Parameters (pages 206–265):
Chapter eight Validation of Mechanistic versions (pages 266–321):
Chapter nine Bioequivalence and Biopharmaceutical class approach (pages 322–339):
Chapter 10 Dose and Particle measurement Dependency (pages 340–346):
Chapter eleven allowing Formulations (pages 347–378):
Chapter 12 foodstuff influence (pages 379–411):
Chapter thirteen Biopharmaceutical Modeling for Miscellaneous circumstances (pages 412–429):
Chapter 14 Intestinal Transporters (pages 430–451):
Chapter 15 procedure in Drug Discovery and improvement (pages 452–458):
Chapter sixteen Epistemology of Biopharmaceutical Modeling and reliable Simulation perform (pages 459–463):
Read or Download Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications PDF
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Extra resources for Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications
34 Eq. 1 Eq. 31 P para Eq. 28 Ptrans P UWL P Eq. 2 Peff Eq. 1 kperm ep Network of equations consisting of the GUT framework. Total Concentration Total concentration of a drug (Ctot ) is the amount of a drug substance in a ﬂuid, regardless of the substance being undissolved solid or dissolved molecules. For example, when 100 mg of a solid drug is diluted to 1 ml with a ﬂuid, the concentration is 100 mg/ml, regardless of whether the drug is completely dissolved or not in the ﬂuid. This point is often miscommunicated by a formulation scientist and a biologist.
P. is the melting point of a drug. p. 41) In this equation, the log Poct reﬂects the hydration energy, and the melting point reﬂects the crystal lattice energy. p. of 100◦ C will change the solubility 10-fold. 4). 42 log units . 41 can be used to diagnose the main reasons for poor solubility. When high lipophilicity is the main reason, micelle solubilization would be effective to increase the solubility of a drug [14–16]. When high melting point is the reason, structural modiﬁcation to reduce the lattice energy would be effective, for example, introducing a steric barrier for molecular stacking or removing an intermolecular hydrogen bond in the crystalline.
P. 41) In this equation, the log Poct reﬂects the hydration energy, and the melting point reﬂects the crystal lattice energy. p. of 100◦ C will change the solubility 10-fold. 4). 42 log units . 41 can be used to diagnose the main reasons for poor solubility. When high lipophilicity is the main reason, micelle solubilization would be effective to increase the solubility of a drug [14–16]. When high melting point is the reason, structural modiﬁcation to reduce the lattice energy would be effective, for example, introducing a steric barrier for molecular stacking or removing an intermolecular hydrogen bond in the crystalline.