Read e-book online Biotechnology and Biopharmaceuticals: Transforming Proteins PDF

By Rodney J. Y. Ho

Biotechnology and Biopharmaceuticals: remodeling Proteins and Genes into medications defines biotechnology from the viewpoint of prescription drugs. the 1st part makes a speciality of the method of reworking a biologic macromolecule right into a healing agent, whereas the second one part offers a short review of every classification of macromolecule with admire to physiological function and medical program. extra element is additionally supplied within the moment part for every FDA licensed, recombinantly derived biopharmaceutical for every classification of macromolecule. the ultimate part seems to be to the longer term and the hot advances that might improve our skill to advance new macromolecules into powerful biopharmaceuticals. This final part discusses numerous drug supply innovations whereas additionally describing gene and mobilephone treatment suggestions.

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The evolution of biotech. Nat. Rev. Drug Discov. 1 : 845–846. , and H. Derendorf. 1997. Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling. Int. J. Clin. Pharmacol. Ther. 35 : 401–413. , and B. Meibohm. 1999. Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharm. Res. 16 : 176–185. B. Sheiner. 1982. Kinetics of pharmacologic response. Pharmacol. Ther. 16 : 143–166. , W. Colburn, G. Heath, T. Lenehan, and T. Kotschwar. 2000. Faster Drug Development.

This effect would prolong the drug’s therapeutic activity, which might be beneficial if the complex formation does not decrease therapeutic activity [43]. Immunogenicity may be affected by the route of administration. Extravascular injection has been shown to stimulate antibody formation more than IV application, but this is most likely due to the increased immunogenicity of protein aggregates and precipitates formed at the injection site [44]. A recent study investigated the effect of the route of administration of INF-b preparations on inducing anti-INF-b antibodies in multiple sclerosis patients.

Monoclonal antibodies market. Nat. Rev. Drug Discov. 3 : 383–384. 24 Griffiths, S. 2004. Betting on biogenerics. Nat. Rev. Drug Discov. 3 : 197–198. 25 EMEA. 2005. Guideline on Similar Biological Medicinal Products. European Agency for the Evaluation of Medicinal Products, London. 1 Introduction Although small numbers of peptide- and protein-based therapeutics have long been used in medical practice (e. , calcitonin or glucagon), it has been the advances in biotechnology and their application in drug development that have propelled peptides and proteins from niche products to mainstream therapeutics.

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